Am Pharma

Tenolam Tablet is a combination of two anti-HIV medicines: Lamivudine and Tenofovir disoproxil fumarate. They prevent HIV (virus) from multiplying, thereby reducing the amount of virus in your body. They also increase the CD4 cell (white blood cells that protect against infection) count in your blood..

Viraday Tablet is a combination of antiretrovirals medicines. It is prescribed to treat HIV (human immunodeficiency virus) infection. It boosts up the immunity to fight against HIV to manage or treat AIDS (acquired immunodeficiency syndrome).

Vonavir Tablet is a combination of three antiviral medicines: Emtricitabine, Tenofovir disoproxil fumarate and Efavirenz. They work by preventing HIV (virus) from multiplying, thereby reducing the amount of virus in your body.

Inbec Tablet (Abacavir) Uses:

Inbec Tablet contains Abacavir, a nucleoside reverse transcriptase inhibitor (NRTI) used for the treatment of HIV-1 infection in combination with other antiretroviral medications. Abacavir works by inhibiting the reverse transcriptase enzyme, which is essential for the replication of HIV, thereby reducing the viral load in the blood.

Uses of Inbec (Abacavir) Tablet:

1. Treatment of HIV-1 Infection:

   • Inbec tablets are used as part of highly active antiretroviral therapy (HAART) to manage HIV infection in adults and children.
   • When taken correctly, it helps lower the viral load, maintain immune function, and delay the progression to AIDS.

2. Pre-exposure Prophylaxis (PrEP) (Off-label use in some cases):

   • In some specific scenarios, Abacavir-containing regimens may be used in individuals at high risk of HIV infection, but this is less common compared to other medications.

How Abacavir Works:

• Abacavir is an NRTI that mimics natural nucleosides used by HIV during replication.
• It gets incorporated into the viral DNA during replication, resulting in chain termination and preventing the virus from multiplying.

Common Side Effects:

• Nausea
• Headache
• Fatigue
• Diarrhea
• Loss of appetite

Serious Side Effects:

1. Hypersensitivity Reaction:
   • A potentially life-threatening hypersensitivity reaction can occur in patients with a specific genetic marker (HLA-B*5701). Genetic testing is recommended before starting Abacavir. Symptoms include fever, rash, nausea, vomiting, and difficulty breathing.
2. Lactic Acidosis:
   • Rare but serious, involving a build-up of lactic acid in the blood, which can be fatal if untreated. Symptoms include muscle pain, weakness, and breathing difficulties.
3. Liver Toxicity:
   • Patients with pre-existing liver disease or hepatitis may experience liver toxicity, requiring regular liver function tests.
4. Heart Problems:
   • Abacavir may increase the risk of cardiovascular events in some patients.

Precautions:

1. HLA-B*5701 Testing:
   • All patients should undergo genetic testing for the HLA-B*5701 allele before starting treatment to avoid hypersensitivity reactions.
2. Avoid Alcohol:
   • Alcohol can increase the risk of liver damage and may worsen side effects like nausea.
3. Pregnancy and Breastfeeding:
   • Inbec (Abacavir) can be used during pregnancy if the benefits outweigh the risks. However, HIV-positive mothers are generally advised not to breastfeed to prevent HIV transmission to the baby.

350mg Dolutegravir Tablet Uses:

Dolutegravir is an integrase strand transfer inhibitor (INSTI) used in the treatment of HIV (Human Immunodeficiency Virus) infection. It works by inhibiting the integrase enzyme, which HIV needs to insert its genetic material into the host cell's DNA, thereby preventing the virus from replicating and spreading.

Uses of 350mg Dolutegravir Tablet:

1. HIV Treatment (Antiretroviral Therapy):

   • Dolutegravir is used as part of combination antiretroviral therapy (cART) for the treatment of HIV-1 infection. It is typically combined with other HIV medications (such as nucleoside reverse transcriptase inhibitors or NRTIs) to help control viral replication and reduce viral load in people with HIV.
   • It is effective in both treatment-naive individuals (those who have never been treated for HIV) and treatment-experienced individuals (those who have previously received antiretroviral therapy).

2. Prevention of HIV Transmission (in combination with other drugs):

   • Dolutegravir may be used as part of a treatment regimen for prevention of mother-to-child transmission (PMTCT) during pregnancy to prevent the transmission of HIV to the unborn child. Pregnant women with HIV are typically treated with a combination of antiretroviral medications to reduce the risk of transmitting the virus.

3. HIV Viral Load Reduction:

   • Dolutegravir helps to reduce HIV viral load to undetectable levels when used as part of an effective treatment regimen. Reducing viral load is important for improving the immune system’s function and preventing the progression to AIDS (Acquired Immunodeficiency Syndrome).

4. Treatment in Co-infection with Hepatitis B:

   • Dolutegravir may also be used in combination with other drugs to treat patients co-infected with HIV and hepatitis B virus (HBV), as dolutegravir can be effective in managing both infections.

Twinaqt Dolutegravir Tablet is a combination medication used to treat HIV (Human Immunodeficiency Virus) infection. It contains Dolutegravir, an integrase strand transfer inhibitor (INSTI), which works by blocking the integrase enzyme that HIV needs to replicate and spread within the body.

Main Uses of Twinaqt Dolutegravir Tablet:

1. HIV-1 Infection:

   • Twinaqt is primarily used for the treatment of HIV-1 infection. Dolutegravir, the active ingredient, helps to reduce the amount of HIV in the body (viral load) and improves the function of the immune system.
   • It is typically used as part of a combination therapy regimen along with other antiretroviral drugs. Combination therapy is recommended to prevent the virus from developing resistance to the medications.

2. Prevention of HIV Progression:

   • By lowering the viral load, Twinaqt Dolutegravir Tablet helps prevent immune system deterioration, thereby reducing the risk of developing AIDS (Acquired Immunodeficiency Syndrome) and related complications.

3. Adherence to ART (Antiretroviral Therapy):

   • Twinaqt is a fixed-dose combination tablet, meaning it combines Dolutegravir with other antiretroviral drugs (often lamivudine and/or tenofovir). This simplifies the treatment regimen and helps improve patient adherence to the prescribed therapy.

How It Works:

• Dolutegravir, the primary active ingredient in Twinaqt, is an integrase inhibitor. Integrase is an enzyme that HIV uses to insert its genetic material into the host cell’s DNA, a critical step in the HIV replication process.
• By blocking integrase, Dolutegravir prevents the replication of the virus, helping to lower the viral load in the body and increase CD4 cell count (a marker of immune function).

Administration:

• Twinaqt Dolutegravir Tablets are taken orally, typically once daily. The exact dosage and regimen may vary depending on the patient's medical history and treatment plan.
• It is important to follow the prescribed regimen and take the medication consistently at the same time every day to maintain effective viral suppression.

Side Effects:

Common side effects of Twinaqt Dolutegravir Tablets may include:

• Headache
• Diarrhea
• Fatigue
• Insomnia
• Nausea or vomiting
• Abdominal pain

Trustiva Tablet contains Emtricitabine, Tenofovir Disoproxil Fumarate and Efavirenz. Trustiva Tablet works by inhibiting the reverse transcriptase enzyme production, which is necessary to multiply the viruses. This effect helps to inhibit viral replication and treats HIV infection.
Tenofovir Disoproxil Fumarate is an antiviral medication used to treat 
- Chronic hepatitis B virus (HBV) infection- HIV infections and AIDS in combination with other medicines- Prevent HIV/AIDS among those at high risk before exposure- HIV/AIDS after a needlestick injury or other potential exposure

Tenofovir Disoproxil Fumarate (TDF) is an antiretroviral medication commonly used in the treatment of HIV and chronic hepatitis B. The 300 mg tablets of Tenofovir Disoproxil Fumarate are typically prescribed for the following uses:

1. HIV Infection (Human Immunodeficiency Virus)

• Tenofovir Disoproxil Fumarate is used as part of combination antiretroviral therapy (cART) to treat HIV infection. It works by inhibiting the reverse transcriptase enzyme, which is essential for the replication of HIV. By reducing the amount of HIV in the body, it helps manage the infection, improve immune function, and reduce the risk of transmitting the virus to others.
• It is often prescribed in combination with other antiretroviral medications, such as emtricitabine or lamivudine.

2. Chronic Hepatitis B (HBV)

• Tenofovir Disoproxil Fumarate is used to treat chronic hepatitis B in adults and children. It helps reduce the amount of hepatitis B virus in the body and lowers the risk of liver damage, cirrhosis, and liver cancer (hepatocellular carcinoma). Tenofovir works by inhibiting the reverse transcriptase enzyme, preventing the replication of the hepatitis B virus.
• It is especially useful in patients who are treatment-naive or have not responded to other antiviral therapies.

3. Prevention of HIV (Pre-exposure Prophylaxis - PrEP)

• Tenofovir Disoproxil Fumarate is used as part of a combination regimen for pre-exposure prophylaxis (PrEP) to prevent HIV infection in individuals at high risk. It is typically combined with emtricitabine (the combination is known as Truvada), and when taken consistently, it significantly reduces the risk of acquiring HIV.

How It Works:

• Tenofovir Disoproxil Fumarate is a nucleotide reverse transcriptase inhibitor (NRTI). It works by inhibiting the reverse transcriptase enzyme, which is crucial for the replication of both the HIV and hepatitis B viruses. By blocking this enzyme, the medication prevents the viruses from multiplying and spreading.

Administration:

• The standard dose of Tenofovir Disoproxil Fumarate for adults is typically 300 mg once daily, taken with or without food.
• It is important to follow the prescribed regimen and complete the full course of treatment, as stopping treatment prematurely can lead to resistance or relapse of the infection.

Important Considerations:

• Side Effects: Common side effects may include nausea, diarrhea, headache, and fatigue. Serious side effects include kidney problems, bone mineral density loss, and lactic acidosis (a buildup of lactic acid in the blood).
• Kidney Function: Tenofovir can affect kidney function, so renal function should be monitored regularly, especially in patients with pre-existing kidney conditions.
• Bone Health: Long-term use of Tenofovir Disoproxil Fumarate can lead to a decrease in bone mineral density, increasing the risk of fractures.
• Drug Interactions: Tenofovir may interact with other medications, so it is important to inform the healthcare provider of any other drugs being taken, including over-the-counter medications and supplements.

Important: Tenofovir Disoproxil Fumarate should be prescribed and monitored by a healthcare provider, particularly an HIV specialist or hepatologist, due to the potential side effects and necessary monitoring during treatment.

Maraviroc (brand name Selzentry) is an antiretroviral medication used to treat HIV (Human Immunodeficiency Virus) infection. The 150 mg Maraviroc tablet is typically prescribed as part of a combination therapy regimen for patients who have specific HIV strains. Below are the primary uses of Maraviroc:

1. Treatment of HIV-1 Infection:

• Maraviroc is used in the treatment of HIV-1 infection, the strain of HIV responsible for the majority of global HIV cases.
• It is used as part of combination antiretroviral therapy (ART) in patients who have already been exposed to HIV and are infected with the virus. It works alongside other antiretroviral drugs to suppress HIV replication and reduce viral load, improving the patient's immune system and reducing the risk of transmission.
• Maraviroc is specifically used for patients with CCR5-tropic HIV-1. HIV uses a specific co-receptor on CD4+ T cells (CCR5 or CXCR4) to enter and infect cells. Maraviroc blocks the CCR5 receptor, preventing the virus from entering the cells, thus inhibiting its ability to replicate.

2. Use in Treatment-Experienced Patients:

• Maraviroc is typically prescribed for treatment-experienced patients, meaning those who have already undergone prior antiretroviral therapy and have HIV strains that are resistant to some other drugs.
• The use of Maraviroc in combination therapy can help overcome resistance to other classes of HIV medications.

Mechanism of Action:

• Maraviroc works as a CCR5 antagonist. It selectively binds to the CCR5 receptor on the surface of CD4+ T cells, which is one of the entry points used by HIV to infect cells. By blocking this receptor, Maraviroc prevents HIV from entering and infecting these cells, reducing the viral load in the body.

Dosage:

• Maraviroc is typically taken as 150 mg, 300 mg, or 600 mg tablets, depending on the patient's regimen and other medications being taken.
• The 150 mg dose is usually taken twice daily, but the dose can be adjusted depending on the patient's overall health, liver function, and any potential interactions with other medications.
• Maraviroc should always be taken in combination with other antiretroviral drugs to ensure effectiveness and to reduce the risk of resistance.

Common Side Effects:

• Cough
• Fever
• Rash
• Abdominal pain
• Dizziness
• Upper respiratory tract infections (e.g., sinusitis, pharyngitis)

Serious Side Effects:

• Liver problems: Maraviroc can cause liver toxicity, with elevated liver enzymes or jaundice in some patients.
• Allergic reactions: Severe reactions, including hypersensitivity or rashes, may occur, and treatment should be stopped if these develop.
• Cardiovascular issues: Maraviroc has been associated with an increased risk of heart problems, including postural hypotension and other cardiovascular events.
• Increased risk of infections: By suppressing HIV, Maraviroc helps improve immune function, but it may also increase the risk of infections, including opportunistic infections.

Dolutegravir Sodium 50 mg Tablets are primarily used as part of antiretroviral therapy (ART) to treat HIV (Human Immunodeficiency Virus) infection. Dolutegravir is an integrase strand transfer inhibitor (INSTI), which works by blocking an enzyme (integrase) that HIV needs to replicate in the body. 

Tafero EM Tablet belongs to a group of medicines called antiretrovirals. It is used to treat HIV (human immunodeficiency virus), the virus that can cause AIDS (acquired immunodeficiency syndrome). It helps to control HIV infection so your immune system can work better.

Tafero EM Tablet�belongs to a group of medicines called antiretrovirals. It is�used�to treat HIV (human immunodeficiency virus), the virus that can cause AIDS.

Tafero EM Tablets typically refer to a combination medication used in the treatment of HIV/AIDS. It contains two active ingredients: Tenofovir disoproxil fumarate (TDF) and Emtricitabine (FTC). These are antiretroviral drugs that are used as part of a combination therapy for managing HIV infection.

Main Uses of Tafero EM Tablets:

1. Treatment of HIV Infection:

   • Tafero EM Tablets are used as part of a combination antiretroviral therapy (cART) to treat human immunodeficiency virus (HIV) infection in adults and children over a certain age. This combination of Tenofovir disoproxil fumarate and Emtricitabine helps reduce the viral load (the amount of HIV in the blood) and improve the immune system by increasing the number of CD4 cells, which are important for immune function.
   • The drug works by inhibiting two important enzymes in the replication of the HIV virus: reverse transcriptase. By blocking the replication of the virus, it reduces the viral load and helps prevent the progression of HIV to acquired immunodeficiency syndrome (AIDS).

2. Prevention of HIV Transmission (Pre-exposure Prophylaxis, PrEP):

   • Although Tafero EM is primarily used in the treatment of HIV, it may also be part of pre-exposure prophylaxis (PrEP) regimens for HIV-negative individuals who are at high risk of acquiring HIV. PrEP involves taking Tenofovir disoproxil fumarate and Emtricitabine to reduce the risk of contracting HIV in individuals who are at risk, such as those with HIV-positive partners or individuals engaging in high-risk sexual behaviors.

3. Prevention of HIV Transmission from Mother to Child:

   • In pregnant women with HIV, Tafero EM Tablets may be used to reduce the risk of mother-to-child transmission of HIV. The medication is often combined with other antiretrovirals to help prevent the transmission of HIV during childbirth or breastfeeding.

How It Works:

• Tenofovir disoproxil fumarate (TDF) and Emtricitabine (FTC) are both nucleoside reverse transcriptase inhibitors (NRTIs).
  • Tenofovir works by interfering with the reverse transcriptase enzyme, which is responsible for converting HIV's RNA into DNA, a critical step in the viral replication process.
  • Emtricitabine also blocks reverse transcriptase, further inhibiting the HIV replication cycle.
• By blocking reverse transcriptase, both drugs prevent the virus from multiplying, thus helping to control the infection and reduce viral load in the bloodstream.

Administration:

• Tafero EM Tablets are usually taken orally once a day with or without food, as directed by a healthcare provider.
• The dosage is typically adjusted based on the patient's specific condition and overall health.

Tafero EM Tablet is a combination antiretroviral medication containing Tenofovir Disoproxil Fumarate (TDF), Emtricitabine (FTC), and Efavirenz (EFV). It is commonly used in the treatment of HIV-1 (Human Immunodeficiency Virus type 1) infection.

Primary Uses of Tafero EM Tablet (25mg tablet):

1. Treatment of HIV-1 Infection:

   • Tafero EM is primarily used for the treatment of HIV-1 infection in adults and children. It is a fixed-dose combination of three different classes of antiretroviral medications:
     • Tenofovir Disoproxil Fumarate (TDF): A nucleotide reverse transcriptase inhibitor (NRTI) that blocks the reverse transcriptase enzyme, preventing the conversion of HIV RNA to DNA and stopping viral replication.
     • Emtricitabine (FTC): A nucleoside reverse transcriptase inhibitor (NRTI) that also inhibits reverse transcriptase, preventing HIV from replicating.
     • Efavirenz (EFV): A non-nucleoside reverse transcriptase inhibitor (NNRTI) that directly inhibits reverse transcriptase, blocking HIV from replicating.
   • This combination is used as part of antiretroviral therapy (ART) to reduce the HIV viral load, improve immune function, and reduce the risk of transmission to others.

2. First-Line HIV Treatment:

   • Tafero EM is typically used as a first-line therapy in patients who are starting treatment for HIV-1 infection, especially in treatment-naive patients (those who have not been previously treated for HIV).
   • This combination is widely used because it has a high efficacy rate and is well-tolerated by many patients.

3. Prevention of HIV Transmission:

   • In addition to treatment, Tafero EM may also be used as part of a prevention strategy (pre-exposure prophylaxis or PrEP) in high-risk individuals to prevent HIV infection. This is commonly prescribed for people who may be exposed to HIV through sexual contact or intravenous drug use.

Lazid N Tablet is a combination of three antiviral medicines: Lamivudine, Zidovudine and Nevirapine. They work by preventing HIV (virus) from multiplying, thereby reducing the amount of virus in your body. They also increase the CD4 cell (white blood cells that protect against infection) count in your blood.

Lazid-N is a combination of Zidovudine, Lamivudine, and Nevirapine, antiretroviral medications used in the treatment of HIV infection. This combination helps reduce the viral load in the body, improves immune function, and decreases the risk of complications related to HIV

Virem 600mg Tablet is an antiviral or antiretroviral medicine. It is�used in the treatment of HIV infection. It stops the virus from producing new viruses and clears up your infection.